Mohs & Histopathology Insights – June 2025

🔍 Equivariant Imaging Biomarkers Enhance Histopathology Segmentation

A new study presents a machine learning model that accounts for image orientation, improving segmentation accuracy in digital pathology workflows. This approach enhances the reliability of unsupervised histopathological image classification, with promising results on prostate tissue samples.

🔗 Read the study on arXiv

🩺 Mohs Surgery Demonstrates Superior Outcomes in Anogenital SCC

A meta-analysis of 70 studies confirms that Mohs micrographic surgery (MMS) yields lower recurrence rates (5%) for anogenital squamous cell carcinoma compared to wide local excision (17.7%). This reinforces MMS as the gold standard in tissue-conserving, high-precision cancer treatment.

🔗 See full analysis at DermSquared

🔬 AI Model Predicts Gene Expression from Histopathology Images

Researchers have introduced PathGen, an AI platform that generates gene expression profiles from histopathological images. This tool improves diagnostic accuracy, grading, and personalized cancer care by merging visual and genomic insights.

🔗 Explore the study on arXiv

🎧 Podcast Pick:

The Future of Dermatology

Hosted by Dr. Faranak Kamangar, this podcast explores emerging topics in dermatology, including AI integration, inflammatory skin diseases, and patient care models. An excellent source for clinical and academic perspectives.

🔗 Listen on Podbean

✨ Mohs Lab Spotlight: Integrating AI for Enhanced Diagnostic Accuracy

A U.S.-based Mohs lab has adopted AI-powered software to assist with intraoperative margin detection. This enhancement has improved slide review times and consistency, showcasing the evolving synergy between pathology and automation.

⚡ Troubleshooting Tip (Mohs & Histopathology): Preventing Tissue Folding During Embedding

To minimize tissue folding:

Mohs:

• Flatten tissue fully before freezing
• Use cold embedding medium
• Gently press to eliminate air pockets

Histopathology:‍

• Pre-warm paraffin molds
• Orient tissue evenly
• Avoid overfilling the mold

This ensures optimal slide quality in both workflows.

Stay informed on the latest advancements, lab tips, and global updates in Mohs surgery and histopathology by visiting www.mohsnews.com monthly. For more detailed information and resources, visit www.mohspro.com. We are #theoriginalmohspros.